Multiscale Physics of Morphogenesis
Our aim is to reverse-engineer the development of embryos by combining physical modeling, computer science and artificial intelligence.
We work in tight collaboration with developmental biologists to implement a holistic and multiscale approach of early embryogenesis across species.
We develop an integrated computational framework, Virtual Embryo, to analyze and simulate and the development of early embryos and small tissues.
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“The morphologist is, ipso facto, a student of physical sciences”
“What I cannot create, I don’t understand. ”
K. Yamamoto, S. Ichbiah, …, H. Turlier, G. Charras Developmental Cell 2026
E. Neiva, H. Turlier, Journal of Computational Physics 2026
A. Pasqui, et al., VertAX
H. De Belly, A. Fernandez Gallen, E. Strickland, D.C. Estrada, P.J. Zager, J.K. Burkhardt, H. Turlier*, O.D. Weiner*, Nat Cell Biol 2026
S. Ichbiah, A. Sinha, F. Delbary, H. Turlier, ICCV 2025
A. Pasqui, S. Mahdavi, B. Vianay, A. Colin, R. Dumollard, A. McDougall, Y.A. Miroshnikova, E. Labrune, H. Turlier*, arXiv:2503.04843.
J. Firmin, N. Ecker, D. Rivet Danon, V. Barraud Lange, H. Turlier, C. Patrat, J-L. Maître, Nature (2024)
A. Rosfelter, G. de Labbey, J. Chenevert, R. Dumollard, S. Schaub, Z. Machaty, L. Besnardeau, C. Hebras, H. Turlier*, D. Burgess*, A. Mcdougall*, J Cell Science 2024
S. Ichbiah, F. Delbary, A. Mcdougall, R. Dumollard, H. Turlier Nature Methods 20, 1989–1999.
H. de Belly, S. Yan, H. Borja da Rocha, S. Ichbiah, J.P. Town, H. Turlier*, C.J. Bustamante*, O.D. Weiner*, Cell 2023
H. Borja da Rocha, J. Bleyer and H. Turlier*, Journal of the Mechanics and Physics of Solids 2022
M. Le Verge-Serandour, H. Turlier* (2021) Blastocoel morphogenesis: a biophysics perspective. Semin Cell Dev
M. Le Verge-Serandour, H. Turlier* (2021) A hydro-osmotic coarsening theory of biological cavity formation. PLoS Comput Biol 17(9): e1009333.
Alessandro Pasqui won the 1st prize at EELISA student competition for his work across AI and biophysics.
Andreu Fernández Gallén was awarded a prestigious Marie Skłodowska-Curie postdoctoral fellowship
Very happy to announce the preprint of Hudson Borja da Rocha, in collaboration with Jérémy Bleyer: A viscous active shell theory of the cell cortex
Very happy to announce the preprint of Mathieu Le Verge—Serandour, first PhD student of the lab: Physics of blastocoel formation by hydro-osmotic lumen coarsening
Sacha Ichbiah is joining the lab to work on fluorescence image analysis combining deep learning and physical modeling.
We are very happy to have him on board !
Our team is composed of talented physicists, computer scientists, engineers and mathematicians working in close collaboration with biologists.